2020 Publications

In Vivo Activity of QPX7728, an Ultrabroad-Spectrum Beta- Lactamase Inhibitor, in Combination with Beta-Lactams against Carbapenem-Resistant Klebsiella pneumoniae

Mojgan Sabet, Ziad Tarazi, David C. Griffith

In Vitro Activity of the Ultra-Broad-Spectrum Beta-Lactamase
Inhibitor QPX7728 in Combination with Meropenem against
Clinical Isolates of Carbapenem-Resistant Acinetobacter

Kirk Nelson, Debora Rubio-Aparicio, Ruslan Tsivkovski, Dongxu Sun, Maxim Totrov,a Michael Dudley, Olga Lomovskaya

Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii

Olga Lomovskaya, Kirk Nelson,a Debora Rubio-Aparicio, Ruslan Tsivkovski, Dongxu Sun, Michael N. Dudley

Biochemical Characterization of QPX7728, a New Ultrabroad- Spectrum Beta-Lactamase Inhibitor of Serine and Metallo- Beta-Lactamases

Ruslan Tsivkovski, Maxim Totrov, Olga Lomovskayaa

In Vitro Activity of the Ultrabroad-Spectrum-Beta-Lactamase Inhibitor QPX7728 against Carbapenem-Resistant Enterobacterales with Varying Intrinsic and Acquired Resistance Mechanisms

Kirk Nelson, Debora Rubio-Aparicio, Dongxu Sun, Michael Dudley, Olga Lomovskaya

Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases

Olga Lomovskaya, Ruslan Tsivkovski, Kirk Nelson, Debora Rubio-Aparicio, Dongxu Sun, Maxim Totrov, Michael N. Dudley

Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases

Scott J. Hecker,* K. Raja Reddy, Olga Lomovskaya, David C. Griffith, Debora Rubio-Aparicio, Kirk Nelson, Ruslan Tsivkovski, Dongxu Sun, Mojgan Sabet, Ziad Tarazi, Jonathan Parkinson, Maxim Totrov, Serge H. Boyer, Tomasz W. Glinka, Orville A. Pemberton, Yu Chen,
and Michael N. Dudley

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