Publications

2022

 

03/22 - A synthetic lipopeptide targeting top-priority multi-drug resistant Gram-negative pathogens

Kade D. Roberts, Yan Zhu, Mohammad A.K. Azad, Mei-Ling Han, Jiping Wang, Lynne Wang, Heidi H. Yu, Andrew S. Horne, Jo-Anne Pinson, David Rudd, Nicolas H. Voelcker, Nitin A. Patil, Jinxin Zhao, Xukai Jiang, Jing Lu, Ke Chen, Olga Lomovskaya, Scott J. Hecker, Philip E. Thompson, Roger L. Nation, Michael N. Dudley, David C. Griffith, Tony Velkov, & Jian Li

 

 

03/22 - The Ultrabroad-Spectrum Beta-Lactamase Inhibitor QPX7728 Restores the Potency of Multiple Oral Beta-Lactam Antibiotics against Beta-Lactamase-Producing Strains of Resistant Enterobacterales

Olga Lomovskaya, Debora Rubio-Aparicio, Ruslan Tsivkovski, Jeff Loutit, Michael Dudley

2021

 

09/21 - Scalable Synthesis of β-Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate

Serge H . Boyer, Angela Gonzalez-de-Castro, J.A. Hubertus Dielemans, Laurent Lefort, Zuolin Zhu, Matthias Gnahn, Julia ​Schörghuber​, Stefan Steinhofer, André H. M. de Vries​, and Scott J. Hecker

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07/21 - QPX7728, An Ultra-Broad-Spectrum B-Lactamase Inhibitor for Intravenous and Oral Therapy: Overview of Biochemical and Microbiological Characteristics

Olga Lomovskaya, Ruslan Tsivkovski, Dongxu Sun, Raja Reddy, Maxim Totrov, Scott Hecker, David Griffith, Jeffery Loutit, and Michael Dudley

06/21 - In Vitro Activity of the Ultra-Broad-Spectrum Beta-lactamase Inhibitor QPX7728 in Combination with Multiple Beta-Lactam Antibiotics against Pseudomonas aeruginosa

Olga Lomovskaya, Debora Rubio-Aparicio, Kirk Nelson, Dongxu Sun, Ruslan Tsivkovski, Mariana Castanheira, Jill Lindley, Jeffery Loutit and Michael Dudley.

2020

 

11/20 - In Vivo Activity of QPX7728, an Ultrabroad-Spectrum Beta- Lactamase Inhibitor, in Combination with Beta-Lactams against Carbapenem-Resistant Klebsiella pneumoniae

Mojgan Sabet, Ziad Tarazi, David C. Griffith

11/20 - In Vitro Activity of the Ultra-Broad-Spectrum Beta-Lactamase
Inhibitor QPX7728 in Combination with Meropenem against
Clinical Isolates of Carbapenem-Resistant Acinetobacter baumannii

Kirk Nelson, Debora Rubio-Aparicio, Ruslan Tsivkovski, Dongxu Sun, Maxim Totrov, Michael Dudley, Olga Lomovskaya

08/20 - In Vitro Activity of the Ultrabroad-Spectrum-Beta-Lactamase Inhibitor QPX7728 against Carbapenem-Resistant Enterobacterales with Varying Intrinsic and Acquired Resistance Mechanisms

Kirk Nelson, Debora Rubio-Aparicio, Dongxu Sun, Michael Dudley, Olga Lomovskaya

06/20 - Impact of Intrinsic Resistance Mechanisms on Potency of QPX7728, a New Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases in Enterobacteriaceae, Pseudomonas aeruginosa, and Acinetobacter baumannii

Olga Lomovskaya, Kirk Nelson, Debora Rubio-Aparicio, Ruslan Tsivkovski, Dongxu Sun, Michael N. Dudley

06/20 - Biochemical Characterization of QPX7728, a New Ultrabroad- Spectrum Beta-Lactamase Inhibitor of Serine and Metallo- Beta-Lactamases

Ruslan Tsivkovski, Maxim Totrov, Olga Lomovskaya

06/20 - Spectrum of Beta-Lactamase Inhibition by the Cyclic Boronate QPX7728, an Ultrabroad-Spectrum Beta-Lactamase Inhibitor of Serine and Metallo-Beta-Lactamases: Enhancement of Activity of Multiple Antibiotics against Isogenic Strains Expressing Single Beta-Lactamases

Olga Lomovskaya, Ruslan Tsivkovski, Kirk Nelson, Debora Rubio-Aparicio, Dongxu Sun, Maxim Totrov, Michael N. Dudley

2020 - Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases

Scott J. Hecker, K. Raja Reddy, Olga Lomovskaya, David C. Griffith, Debora Rubio-Aparicio, Kirk Nelson, Ruslan Tsivkovski, Dongxu Sun, Mojgan Sabet, Ziad Tarazi, Jonathan Parkinson, Maxim Totrov, Serge H. Boyer, Tomasz W. Glinka, Orville A. Pemberton, Yu Chen, and Michael N. Dudley